The issue of suicide and its prevention has garnered significant attention globally, yet the effectiveness of interventions often hinges on cultural nuances and specificities. Ukraine’s history is marked by periods of oppression, conflict, and instability, contributing to a complex socio-cultural landscape that impacts mental health and attitudes towards seeking help. Stigma associated with mental health issues, rooted in Soviet-era perceptions and the valorization of stoicism, presents a significant barrier to suicide prevention. This stigma not only deters individuals from seeking help but also influences the availability and approach of support services, which often lack the resources or training to address suicide effectively and sensitively. The ongoing conflict in Ukraine, with its profound and pervasive impacts on the national psyche and individual mental health, significantly complicates the landscape of suicide prevention and postvention. The trauma of war, including displacement, loss of loved ones, and direct exposure to violence, exacerbates mental health issues and elevates the risk of suicide among both civilians and veterans. The war has not only intensified stressors and mental health challenges but also strained the already limited mental health services and resources available. Moreover, the cultural valorization of heroism and resilience in the face of adversity may further discourage individuals affected by the war from seeking help for mental health issues, for fear of being perceived as weak. The intersection of these factors demands an urgent and tailored response that considers the specific mental health needs engendered by the conflict, ensuring that suicide prevention and postvention strategies are robust, sensitive, and accessible to all affected by the war in Ukraine. Furthermore, the role of the Orthodox Church in Ukraine introduces both challenges and opportunities for suicide prevention and postvention. In conclusion, addressing the cultural specificities and barriers to suicide prevention and postvention in Ukraine requires a multifaceted strategy especially during the war. By acknowledging and navigating cultural challenges, there is potential to create more effective and accessible interventions for those in crisis and their families, ultimately reducing the incidence and impact of suicide in Ukraine.