Classical suicidology first posited that the suicidal individual experiences unbearable psychological pain (psychache) or suffering and that suicide might be, at least in part, an attempt to escape from this suffering. According to this model, psychache is the main ingredient of suicide risk because it is an escape from intolerable suffering, emphasizing that suicide is not a movement toward death but an escape from unbearable emotion, unendurable or unacceptable anguish. Suicide is a major leading cause of death among adolescents, and recent international data suggest that suicide attempts and deliberate self-harm among adolescent girls are alarmingly higher than in the pre-pandemic period. Recent Italian figures also suggest that girls experience higher levels of distress, low self-esteem, and intensity of negative emotions, which, according to these studies, are related to higher suicide risk. Also, the absence of religious beliefs, low economic status, and attending a lyceum were associated with greater impairment of individual well-being. As protective factors, the association between individual well-being and the quality of social interactions with friends and family is central to the interpersonal theory of suicidal behavior, which emphasizes the relevance of the dimension of thwarted belongingness. This presentation will overview both international and Italian findings related to the emotional challenges faced by adolescents as related to increased suicide risk in recent years. Models for further understanding mental pain, negative emotions, and suicide risk are explored through the presentation.