The effect of the COVID-19 pandemic on suicide deaths remained uncertain. To investigate this, the present study aimed to examine changes in mortality related to suicides at AIIMS, New Delhi from two districts in Delhi, India, as well as other factors such as demographics, clinical data, and social variables, during the period from January 1 to October 31, 2021. The data was classified into three time frames: pre-second wave (January 1 to April 18, 2021), lockdown phase (April 19 to June 7, 2021), and post-lockdown phase (June 8 to October 31, 2021), and compared the results with the corresponding periods during the first wave of the pandemic (pre-first wave from January 1 to March 24, 2020; lockdown phase from March 25 to May 31, 2020; and post-lockdown phase from June 1 to October 31, 2020). Of the 450 suicidal deaths that occurred during the study period, 63 and 214 were reported during the lockdown (50 days) and post-lockdown (146 days) periods, respectively. The corresponding figures for the same period in the previous year were 61 and 260 during the lockdown (68 days) and post-lockdown (153 days) periods, respectively, out of a total of 418 suicidal deaths. There were no significant differences in age (p = 0.20) or gender (p = 0.20) distribution between the lockdown and post-lockdown periods. However, there were significantly fewer suicide deaths related to substance use (p = .02) during the lockdown period (7.9%) compared to the post-lockdown period (20.6%). These results suggest that the impact of the COVID-19 pandemic on suicide deaths varied over time and across different geographic regions. This study provided insights into the pandemic's impact on suicide deaths during the first and second waves. Ongoing surveillance of suicide-related death trends is necessary to understand the pandemic's dynamic character as it continued to spread. These findings can aid researchers in better understanding the pandemic's impact on suicide behavior and the factors that influence it.