The development of digital studies based on the continuous monitoring of patients in their natural environment help to refine the suicidal phenotypes. Ecological momentary assessment using smartphones allow capturing the everyday context and experiences of individuals through repeated measurements in naturalistic environments and then potentially may improve our ability to predict in the short term. Several studies using ecological momentary assessment revealed the existence of different patterns of suicidal ideation (SI) based on both their severity and variability. Specifically, it seems that variable SI may be particularly frequent, up to one third of suicidal ideators. In addition and importantly, such a pattern appears to be related to some clinical features: more instability in social withdrawal, sleep measures, wish to live, and more frequent suicide attempts. A series of study also demonstrated that the high variability pattern, could be a trait, associated with the propensity to experience SI when exposed to stressful life events and this pattern seems to be rooted in childhood trauma, impulsive aggression and emotional reactivity and a pre-existing lower 5-HTT transmission. This means that the description of the suicidal pattern may help to define clinically and biologically homogeneous groups of at risk patients. In this sense, experimental studies where patients are submitted to a social stress task reported that patients who were more sensitive to a social stress, as measured with a higher salivary cortisol response, were less depressed, more impulsive, and made suicide attempts with a higher intent. In order to continue to better characterize subgroups of patients, ongoing studies are investigating the regulation of the immune inflammatory response to the social stress task, as it is well demonstrated that social stressors are strong inducers of an inflammatory response. This combination of studies both digital and experimental could help to refine the suicidal phenotypes and reduce the heterogeneity of suicidal behaviors that are led by different processes. One of the main goal would be to translate the distinct psychobiological alterations characterizing each of the subgroups, into specific therapeutic approaches for a better suicide prevention.