PS21 - Social and Decision Neuroscience of Suicidal Behavior Across the Lifespan
Are Changes in Value-Based Decision-Making Associated With the Choice of a Suicidal Means?Suicidal behavior (SB) is a complex and multifaceted phenomenon that encompasses biological, psychological and environmental factors. They ultimately interact in such an unfavorable way that a person decides to end their life. Deficits in decision making were specifically shown to be altered in persons with past SB biasing their selection of possible alternatives and evaluation of the consequences of their actions in a suicidal crisis. Using the Iowa Gambling Task, it was previously demonstrated that suicide attempters displayed a greater tendency to choose more risky and disadvantageous options. Importantly, these deficits appear to be particularly pronounced among persons who used violent suicidal means (VSM) compared to persons who used non-violent means (NVSM) (Perrain et al., 2020). A personal history of suicide attempt with VSM is the most significant risk factor of future suicide death. Therefore, the main goal of the present study was to identify dimensions of value-based decision-making that differ between individuals who use VSM and those who use NVSM. The current study was conducted on two sites, Jena (Germany) and Nimes (France) between 20222024 as part of a collaborative project funded by the AFSP. We employed four value-based decision-making paradigms comprising a series of financial offers that measure trade-offs among varying amounts, delays, and probabilities (Pooseh et al., 2018). Delay and probability discounting quantify the degree of decline in subjective values of offered amounts with increasing delay and decreasing probability, respectively. Two additional gambling tasks were based on the prospect theory of Kahneman and Tversky (1979), with which group differences in probability discounting for losses and loss aversion were examined. Loss aversion means that people prefer to avoid losses rather than make corresponding gains. The study included four groups: patients with SB using VSM, patients with SB using NVSM, control patients with an affective disorder and healthy control subjects. The results of this study will be presented and discussed regarding differences in the choice of suicidal means.