Introduction: We have previously identified (Galfalvy et al., 2023) four different profiles of suicidal ideation in a long-term follow-up study of middle-aged and older adults. In the present analysis, we compare the profiles on longitudinal depression symptoms and cognition, and test for differential association with ideation over time. Methods: 337 depressed older adults (age 50-93 years), followed for up to 14 years (median=3 years), were divided into four groups: Low/non-ideators (LI, 22.8%), Chronic ideators (CI, 27.6%), Variable ideators (VI, 18.7%), and Fast-remitting ideators (RI, 30.9%) using latent profile analysis. Analysis of variance at baseline, and mixed effect ordinal regression models (with cumulative link) were used to compare the groups on (1) the Hamilton Depression Rating Scale (HDRS; total scores and 16 item scores, excluding the suicide item); and (2) total scores of the Mini Mental State Exam (MMSE). The association between depression and ideation were compared among profiles using mixed effect model with an interaction. Multiple testing adjustment was performed using the Benjamini-Hochberg method. Results: Significant profile differences in the time course of depression were found for 11/16 depression items. Chronic ideators displayed persistently higher scores on depressed mood than the other groups (p<0.001 vs. RI, p = 0.021 vs. VI). In contrast, remitting ideators had a greater improvement of early insomnia (p = 0.016) and insight than low/non-ideators (p = 0.023). Variable ideators had higher scores on the psychic anxiety item at baseline than low/non-ideators (p = 0.011). As expected, depression and ideation scores over time were associated in all three ideator groups, however, the strength of the association was significantly stronger in remitting ideators (p < 0.0001 vs.CI, p < 0.0001 vs.VI). In terms of cognition, chronic and remitting, but not variable ideators, had worse cognitive scores over the study period than the low/non-ideator group (p = 0.035 vs.CI, p = 0.002 vs.RI). Discussion: While suicidal ideation and depression were positively associated across profiles, the profile with the strongest association was that of the remitters, indicating that fast decline in ideation was likely linked to similar fast improvement in depression levels. Poor cognitive scores characterized both the chronic and the remitting ideators, while the variable ideators may have high psychic anxiety.