One population vulnerable to increased risk for suicide are individuals with bipolar disorder. In fact, compared to other psychiatric disorders, bipolar disorder has the highest risk for suicide. However, the biological basis for this vulnerability is not completely understood. The goal of this study was to identify biological and neurobehavioral factors distinct to bipolar disorder that will help further our understanding of suicide in bipolar disorder. Specifically, we utilized the NIH Toolbox, bisulfite sequencing, and arrays to study DNA methylation to test the hypothesis that emotional dysregulation in individuals with bipolar disorder specifically increases vulnerability to suicide, and this is associated with systemic epigenetic changes. We used RNA-sequencing (bipolar disorder N=25, control N=25), genotyping arrays (bipolar disorder N=104, control N=66), and bisulfite sequencing (bipolar disorder N=106, controls N=53) to identify biological differences in participants diagnosed with bipolar disorder, with and without suicidal behavior, compared to controls. We also compared molecular changes to a variety of neurobehavioral aspects recorded using the NIH Toolbox including cognition and stress response. Multiple genes were significantly differentially methylated in individuals with bipolar disorder and a history of suicide attempt including TGFBR1 (adjusted p-value=2.96x10-4) and FKBP5 (adjusted p-value=0.036), two genes also associated with stress response. Notably, methylation of a CpG site in CACNA1C was correlated with severity of attempt (FDR=0.048). We present a pilot study investigating the role of DNA methylation and emotional dysregulation in increasing the risk for suicidal behavior in individuals with bipolar disorder. Preliminary data suggests a highly relevant epigenetic component to emotional dysregulation in bipolar disorder and suicide.