Introduction. Suicide is among the leading causes of preventable death worldwide. The impact of suicide affects the personal, social, and economic levels. The development of information and communication technologies has created new opportunities and challenges in prevention, research and clinical practice focused on decreasing the probability of suicide attempts in high-risk patients. Suicide prevention programs based on telephone management treatments report moderate adherence, with this type of intervention being well valued and accepted by patients. Objectives. The aim is to carry out a clinical and sociodemographic profile of individuals with high adherence to treatment vs. low adherence to treatment. In addition, we intend to analyze the moderating effect of adherence on the efficacy of telephone follow-up by comparing a group with high adherence vs. a group with lower adherence vs. a control group. Methods. A coordinated randomized multi-center clinical trial was conducted to test telephone-managed secondary prevention programs to prevent suicide versus TAU, as a part of a prospective cohort of individuals presenting a suicide attempt (SURVIVE project). The primary outcome was the subsequent suicide attempts (and/or suicide mortality). The secondary variables were adherence to the telephone intervention program; mental health diagnosis; seriousness of suicidal behavior; characteristics of the suicide attempt; sociodemographic variables; impulsivity; adherence to pharmacological treatment; acquired capacity for suicide; and potential lethality of the method, among others. A total of 568 participants were recruited, n = 273 in the telephone management intervention group and n = 295 in the control group (TAU). Results. The analysis of clinical predictor variables and sociodemographic factors associated with adherence to a telephone intervention program in an adult population with a previous suicide attempt will be presented in the results section. Conclusions. The prediction of adherence to telehealth treatment after a suicide attempt is a key element in the evaluation of the feasibility and viability of the intervention. At the present time, the existence of sociodemographic and clinical variables that could be related to the dropout rate is not yet clearly determined. Identifying symptom clusters related to therapeutic adherence in persons discharged from the emergency department after a self-harm attempt may lead to advances in clinical practice.