Background: Clinical guidelines recommend psychosocial interventions to help prevent self-harm repetition and suicide. However, access to aftercare remains patchy, which may reflect poor translation of complex evidence to practice. Objectives: We conducted an umbrella review (review of reviews) to evaluate the effects of psychosocial interventions for self-harm and suicide across healthcare settings between 2010 and 2024. Methods: Reviews with or without meta-analysis were identified via key databases (Medline, Embase, CINAHL, Cochrane Database of Systematic Reviews), citation and hand searches. Methodological quality and evidence certainty were evaluated using AMSTAR-2 and GRADE respectively. Results: Initial database and manual searches found 1116 systematic reviews, of which 49 were included in the final review. Results will be shared on effectiveness, methodological quality, and clinical application of interventions for self-harm and suicide prevention. Conclusion: Patients can present across multiple healthcare settings, and it may be challenging to understand what interventions work for whom and where. We provide a clinically useful, concise overview of the most recent evidence of psychosocial interventions from systematic reviews to guide treatment decisions in real-world clinical practice.