Background. Despite a decline in suicide rates in Slovenia, the country's suicide mortality rate remains higher than the WHO European Region average. This study aimed to investigate suicide methods in Slovenia, by examining trends between 2001 and 2020 and exploring the relationship between suicide methods and selected sociodemographic characteristics to inform targeted interventions and prevention strategies. Methods. We analyzed intentional self-harm deaths (X60-X84). Joinpoint regression analysis was used to assess changes in age-standardized suicide rates by method and gender, while multivariate logistic regression analysis was used to estimate associations between sociodemographic characteristics and specific suicide methods. Results. Certain associations were found between socio-demographics and specific suicide methods, with men using especially firearms and hanging and women using prescription drugs, drowning, jumping from height and jumping or laying in front of a moving object, the latter being more prevalent among younger individuals. Suicide rates have declined for most methods in both genders, except for those involving sharp objects and jumping or laying in front of a moving object. Discussion. Understanding the relationship between sociodemographic characteristics and suicide methods is an important step for developing effective prevention strategies. The results of the study can be built upon to develop strategies towards restriction of specific suicide methods which were shown to be associated with certain sociodemographic groups, e.g firearms in men, jumping from height in women and jumping or laying in front of a moving object among young people. The findings suggest that there is a need for continuing ongoing efforts to restrict both cognitive (e.g. by collaboration with the media) and physical availability of the means.